Chemical name: Methanimidamide, N'-(4-chloro-2-methylphenyl)-N,N-dimethyl- Final regulatory action has been taken for the category: Pesticide Final regulatory action: The chemical is Banned Use or uses prohibited by the final regulatory action: All uses are banned Pesticide use or uses that remain allowed: All uses are banned The final regulatory action was based on a risk or hazard evaluation: Yes Summary of the final regulatory action: The substance is banned by an order of the Ministry of Health of the ex-USSR and by the Ordinance of the Government of the Kyrgyz Republic of 27 June 2001 No. 376. The reasons for the final regulatory action were relevant to: Human health and environment Summary of known hazards and risks to human health: Chloridimeform and its principal metabolites are considered probable human carcinogens. Studies in mice indicate dose-related increased incidence of hemangiosarcomas and hemangiomas-malignant tumours of the blood vessel. These data are reinforced by human monitoring data which link a chlordimeform metabolite 4-chloro-o-toluidine (5-CAT), with bladder cancer. The primary concern is for manufacturing plant and agricultural workers handling or applying the insecticide who are subject to exposure to residues over several years. Animal data indicating carcinogenic potential are reinforced by human urine monitoring data which implicate a chlordimeform metabolite with bladder cancer. Expected effect of the final regulatory action in relation to human health: Reduction of risks and hazards for humans. Summary of known hazards and risks to the environment: Although data are not adequate, chlordimeform and its HCL salt are considered to have little potential for leaching to groundwater. They are relatively immobile in mulch and loam soils and short-lived. Residues may move from a treated site in run-off sediment. Expected effect of the final regulatory action in relation to the environment: Reduction of risks and hazards for the environment. Date of entry into force of the final regulatory action: 27/07/2001 |